Assize Index

Sweeteners

Sucralose

SubstituteSyntheticEveryday Health rank

GI(Glucose = 100)

Primary · 0 GI

High-intensity sweeteners — no available carbohydrate for classical GI (2020)

Energy(kcal/100g)

Primary · 0 kcal/100g

High-intensity sweeteners — no available carbohydrate for classical GI (2020)

Carbs(g/100g)

Primary · 0 g/100g

High-intensity sweeteners — no available carbohydrate for classical GI (2020)

Sugars(g/100g)

Primary · 0 g/100g

High-intensity sweeteners — no available carbohydrate for classical GI (2020)

Functional benefits

No cited minerals or other functional notes on file yet.

Cited minerals can add up to +2 on Best sweetener for everyday health — see Methods.

Risks & side effects

  • High-intensity sweetener

    note

    Use-level and blends matter. Packet fillers are different products. Regulatory class note — not scored.

    FDA — High-intensity sweeteners permitted for use in food (2023)

  • WHO: not for weight control

    caution

    WHO 2023, conditional (low certainty): not for weight control or lowering disease risk — no long-term body-fat benefit. Not a safety ruling. Scored: the energy points it earns over sucrose are taken back on Everyday Health, Weight goals and Easy on the liver; not on Diabetic-friendly (WHO excludes people with diabetes).

    WHO — Use of non-sugar sweeteners: WHO guideline (2023)

  • Impaired glucose response (2-week trial)

    note

    Cell 2022 randomized trial: sucralose impaired glucose tolerance in healthy adults (20 per arm, 2 weeks, below ADI); aspartame and stevia did not. Small and short, a lab measure rather than a disease outcome, and the sachets carried glucose. Scored: glucose signal −7 on Everyday Health and Weight goals (not on Easy on the liver; synthetics are not on Diabetic-friendly).

    Suez et al. — Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance (Cell) (2022)

  • Coronary heart disease link (cohort)

    note

    BMJ 2022 NutriNet-Santé (103,388 adults): HR 1.31 (1.00–1.71). Observational association, not proof of cause. The interval touches 1.00 — borderline. Scored: CV signal −7 on Everyday Health and Weight goals (synthetics are not on Diabetic-friendly; not on Easy on the liver), once per sweetener however many links.

    Debras et al. — Artificial sweeteners and risk of cardiovascular diseases: NutriNet-Santé cohort (BMJ) (2022)

Not medical advice. Published recipe penalties (if any) are on Methods — not a clinical severity scale.

Notes

No extra context notes on file yet.

Notes explain what the open axis or risk labels alone can miss — not medical advice.

An empty cell means we do not yet have a method-cited source. Rank 1 wins the published rule; it is not medical advice.