Saccharin

GI(Glucose = 100)

0^*0^*

Energy(kcal/100g)

0 kcal^*0 kcal^*

Carbs(g/100g)

0 g^*0 g^*

Sugars(g/100g)

0 g^*0 g^*

Functional benefits

No cited minerals or other functional notes on file yet.

Cited minerals can add up to +2 on Best sweetener for everyday health — see Methods.

Risks & side effects

• High-intensity sweetener

  note

  Use-level and blends matter. Packet fillers are different products. Regulatory class note — not scored.

  FDA — High-intensity sweeteners permitted for use in food (2023)

• WHO: not for weight control

  caution

  WHO 2023, conditional (low certainty): not for weight control or lowering disease risk — no long-term body-fat benefit. Not a safety ruling. Scored: the energy points it earns over sucrose are taken back on Everyday Health, Weight goals and Easy on the liver; not on Diabetic-friendly (WHO excludes people with diabetes).

  WHO — Use of non-sugar sweeteners: WHO guideline (2023)

• Impaired glucose response (2-week trial)

  note

  Cell 2022 randomized trial: saccharin impaired glucose tolerance in healthy adults (20 per arm, 2 weeks, below ADI); aspartame and stevia did not. Small and short, a lab measure rather than a disease outcome, and the sachets carried glucose. Contrary trial in Notes (Serrano 2021). Scored: glucose signal −7 on Everyday Health and Weight goals (not on Easy on the liver; synthetics are not on Diabetic-friendly).

  Suez et al. — Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance (Cell) (2022)

Not medical advice. Published recipe penalties (if any) are on Methods — not a clinical severity scale.

Notes

• Contrary trial: pure saccharin at the maximum ADI for 2 weeks (46 healthy adults, double-blind) changed neither glucose tolerance nor gut microbiota. We still score the glucose signal from Cell 2022 and print this beside it.

  Capsules without a glucose vehicle; Cell 2022 sachets carried glucose. Two short trials disagree — neither measured a disease outcome.

  Serrano et al. — High-dose saccharin supplementation does not induce gut microbiota changes or glucose intolerance in healthy humans and mice (Microbiome) (2021)

Notes explain what the open axis or risk labels alone can miss — not medical advice.